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Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract

2021; American Society for Microbiology; Volume: 95; Issue: 14 Linguagem: Inglês

10.1128/jvi.00130-21

1098-5514

Or Alfi, Arkadi Yakirevitch, Ori Wald, Ori Wandel, Uzi Izhar, Esther Oiknine‐Djian, Yuval Nevo, Sharona Elgavish, Elad Dagan, Ory Madgar, Gilad Feinmesser, Eli Pikarsky, Michal Bronstein, Olesya Vorontsov, Wayne B. Jonas, John A. Ives, Joan Walter, Zichria Zakay‐Rones, Menachem Oberbaum, Amos Panet, Dana G. Wolf,

Respiratory viral infections research

The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the imbalanced innate immune response of end-stage coronavirus disease 2019 (COVID-19) has been extensively studied, the earliest stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored. Here, we employed SARS-CoV-2 and influenza virus infection in native multi-cell-type human nasal turbinate and lung tissues