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Treatment of Localized and Locally Advanced, High-Risk Prostate Cancer: A Report From the First Prostate Cancer Consensus Conference for Developing Countries

2021; Lippincott Williams & Wilkins; Issue: 7 Linguagem: Inglês

10.1200/go.20.00421

2687-8941

Raja B. Khauli, Robson Ferrigno, Gustavo Cardoso Guimarães, Muhammad Bulbulan, Pedro Luiz Serrano Usón, Bernardo Peres Salvajoli, Daniel Moore-Palhares, Douglas Jorge Racy, Erlon Gil, Fernando Freire de Arruda, Gustavo Caserta Lemos, Gustavo Franco Carvalhal, Ícaro Thiago de Carvalho, Igor Austin Fernandes Martins, Ivan Frederico Pinto Gimpel, João Víctor Salvajoli, Jose L Chambô, José Aírton de Freitas Pontes, Leopoldo Alves Ribeiro‐Filho, Lucas Nogueira, Marcelo Roberto Pereira Freitas, Marcelo Langer Wroclawski, Marco A. Arap, Marcus Vinícius Sadi, Rafael F. Coelho, Rafael Gadia, Rodrigo Antonio Ledezma Roja, Rodrigo de Morais Hanriot, Ronaldo Hueb Baroni, Stênio de Cássio Zéqui, William Carlos Nahas, Wladimir Alfer, Fernando Cotait Maluf,

Statistical Methods in Clinical Trials

To generate and present survey results on important issues relevant to treatment and follow-up of localized and locally advanced, high-risk prostate cancer (PCa) focusing on developing countries.A panel of 99 PCa experts developed more than 300 survey questions of which 67 questions concern the main areas of interest of this article: treatment and follow-up of localized and locally advanced, high-risk PCa in developing countries. A larger panel of 99 international multidisciplinary cancer experts voted on these questions to create the recommendations for treatment and follow-up of localized and locally advanced, high-risk PCa in areas of limited resources discussed in this article.The panel voted publicly but anonymously on the predefined questions. Each question was deemed consensus if 75% or more of the full panel had selected a particular answer. These answers are based on panelist opinion and not on a literature review or meta-analysis. For questions that refer to an area of limited resources, the recommendations considered cost-effectiveness as well as the possible therapies with easier and greater access. Each question had five to seven relevant answers including two nonanswers. Results were tabulated in real time.The voting results and recommendations presented in this article can guide physicians managing localized and locally advanced, high-risk PCa in areas of limited resources. Individual clinical decision making should be supported by available data; however, as guidelines for treatment of localized and locally advanced, high-risk PCa in developing countries have not been defined, this article will serve as a point of reference when confronted with this disease.