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Falls Predict Acute Hospitalization in Parkinson’s Disease

2021; IOS Press; Volume: 13; Issue: 1 Linguagem: Inglês

10.3233/jpd-212539

1877-718X

Diego Santos‐García, Teresa de Deus Fonticoba, Carlos Cores, E. Suárez Castro, Jorge Hernández‐Vara, Silvia Jesús, Pablo Mir, Marina Cosgaya, Marı́a José Martı́, Pau Pástor, Iria Cabo, Manuel Seijo, I. Legarda, Bárbara Vives, Núria Caballol, Javier Ruiz‐Martínez, Ioana Croitoru, Esther Cubo, Javier Miranda, Maria G. Alonso Losada, Carmen M. Labandeira, Núria López Ariztegui, Mabel Morales-Casado, Isabel González Aramburu, Jon Infante, Sonia Escalante, N. Bernardo, Marta Blázquez Estrada, Manuel Menéndez‐González, Juan García Caldentey, Carmen Borrué, Lydia Vela, María José Catalán, Víctor Gómez‐Mayordomo, Mónica Kurtis, Cristina Párraga Prieto, Carlos Ordás, Víctor Nogueira, Lydia López Manzanares, María A. Ávila Rivera, Víctor Puente, J M García-Moreno, Berta Solano Vila, María Álvarez Saúco, Francisco Carrillo Padilla, Juan Carlos Martínez‐Castrillo, Pilar Sánchez Alonso, Itziar Gastón, Jaime Kulisevsky, Caridad Valero, Oriol de Fábregues, Jessica González Ardura, Luis M. López Díaz, Pablo Martínez‐Martín,

Botulinum Toxin and Related Neurological Disorders

There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission.To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort.PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit.Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH.Falls is an independent predictor of AH in PD patients.