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Changes in Stem Cell Transplant activity and procedures during SARS-CoV2 pandemic in Italy: an Italian Bone Marrow Transplant Group (GITMO) nationwide analysis (TransCOVID-19 Survey)

2021; Springer Nature; Volume: 56; Issue: 9 Linguagem: Inglês

10.1038/s41409-021-01287-w

1476-5365

Domenico Russo, Nicola Polverelli, Michele Malagola, Mirko Farina, Alessandro Leoni, Simona Bernardi, Sonia Mammoliti, Nicoletta Sacchi, Massimo Martino, Fabio Ciceri, Francesco Zallio, Attilio Olivieri, Sadia Falcioni, Gabriella Storti, Mariagrazia Michieli, Paola Carluccio, Anna Grassi, Elena Oldani, Francesca Bonifazi, Arcangelo Prete, Irene Cavattoni, Marianna Maffeis, Domenico Pastore, Adriana Vacca, Daniela Caravelli, M Mirabile, Nicola Mordini, Chiara Nozzoli, Maura Faraci, Vincenzo Federico, Sonia Ronconi, Cristina Skert, Francesco Onida, Magda Marcatti, Simona Piemontese, Franco Narni, Adriana Balduzzi, Giuseppina De Simone, Alessandra Picardi, Marco De Gobbi, Elisabetta Calore, Stefania Tringali, Marco Zecca, Simona Secondino, Barbara Guiducci, Matteo Pelosini, Eliana Zuffa, Luca Facchini, Manuela Imola, Anna Paola Iori, Anna Proia, Simona Sica, Daniele Armiento, Angelo Michele Carella, Chiara Maria Dellacasa, Franca Fagioli, Marco Rabusin, Andrea Ferrario, Francesca Elice,

Hematopoietic Stem Cell Transplantation

The Transplant Centers belonging to Gruppo Italiano per il Trapianto di Midollo Osseo (GITMO) conducted a survey with the aim of evaluating the effect of SARS-CoV2 pandemic on the allogeneic transplant activity in Italy. The pandemic period from 1/3/2020 to 31/7/2020 was compared with the same period in 2019. Overall, in 2020 there was a 2.4% reduction in the number of allo-HCT cases compared to 2019. Interestingly, this deflection did not affect the acute leukemia cases (+5.7% in 2020). The use of peripheral blood-derived stem cells (+10.7%) and cryopreservation (97.4% of the centers) was highly adopted in 2020. Despite the sanitary emergency, almost all of the surveyed centers declared no impact of SARS-CoV2 pandemic on the transplant timing and outcomes, and the sanitary policy was positively evaluated by the majority of centers. The emergency measures ensured that only a minority of the allo-HCT patients had been infected by SARS-CoV2; however, a mortality of 42.1% among the allo-HCT patients hospitalized for COVID-19 was recorded. This survey gives us the information that the GITMO Group reacted positively to the pandemic. Thanks to the emergency strategies, the Italian allo-HCT activity continued safely, showing only a minor deflection and offering the same probability of cure to the transplanted patients.