Produção Nacional
Revisado por pares
Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas
2021; Public Library of Science; Volume: 15; Issue: 4 Linguagem: Inglês
10.1371/journal.pntd.0009290
ISSN1935-2735
AutoresElaine Cristina de Oliveira, Vagner Fonseca, Joilson Xavier, Talita Adelino, Ingra Morales Claro, Allison Fabri, Eduardo Marques Macário, Ana Elisa Viniski, Cláudio Luís Campos Souza, Evanil Sebastiana Gomes da Costa, Claudia Soares de Sousa, Flávia Guimarães Dias Duarte, Arnaldo Correia de Medeiros, Carlos F. Campelo de Albuquerque, Rivaldo Venâncio da Cunha, Noely Fabiana Oliveira de Moura, Ana María Bispo de Filippis, Túlio de Oliveira, José Lourenço, André Luiz de Abreu, Luíz Carlos Júnior Alcântara, Marta Giovanetti,
Tópico(s)Viral Infections and Vectors
ResumoSince introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained transmission, although much is unknown about its circulation in the midwestern states. Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT). Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic and epidemiological approaches were used to explore the recent spatio-temporal evolution and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas. Epidemiological data revealed a reduction in the number of reported cases over 2018-2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeographic reconstructions revealed that at least two independent introductions of the ECSA lineage occurred in MT from a dispersion event originating in the northeastern region and suggest that the midwestern Brazilian region appears to have acted as a source of virus transmission towards Paraguay, a bordering South American country. Our results show a complex dynamic of transmission between epidemic seasons and suggest a possible role of Brazil as a source for international dispersion of the CHIKV-ECSA genotype to other countries in the Americas.
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