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Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon

2021; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 4 Linguagem: Inglês

10.3390/v13040689

1999-4915

Geovani de Oliveira Ribeiro, Danielle Elise Gill, Edcelha Soares D’Athaide Ribeiro, Fred Júlio Costa Monteiro, Vanessa dos Santos Morais, Roberta Marcatti, Márlisson Octávio da Silva Rêgo, Emerson Luiz Lima Araújo, Steven S. Witkin, Fabiola Villanova, Xutao Deng, Éster Cerdeira Sabino, Eric Delwart, Élcio Leal, Antônio Charlys da Costa,

Dengue and Mosquito Control Research

Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (n = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapá. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapá around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapá isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region.