Portal de Periódicos da CAPES

Treating Acute Leukemia During the COVID-19 Pandemic in an Environment With Limited Resources: A Multicenter Experience in Four Latin American Countries

2021; Lippincott Williams & Wilkins; Issue: 7 Linguagem: Inglês

10.1200/go.20.00620

2687-8941

Roberta Demichelis‐Gómez, Martha Alvarado‐Ibarra, Jule F Vasquez, Nancy Delgado-López, Cynthia Gómez-Cortés, Karla Espinosa‐Bautista, Ana Cooke-Tapia, Andrea I. Milán-Salvatierra, Andrés Gómez‐De León, Yu Ling Lee-Tsai, Daniel Estuardo Rosales-Lopez, Álvaro Cabrera-García, Lauro Fabián Amador Medina, Alejandra Córdoba-Ramírez, Iván Murrieta-Álvarez, Juan Carlos Solís-Poblano, Elia Apodaca, Juan Rangel‐Patiño, José L. Álvarez-Vera, Luara L. Arana-Luna, José A. de la Peña-Celaya, María Eugenia Espitia-Ríos, Eleazar Hernández-Ruiz, Juan Manuel Pérez-Zúñiga, Estefanía Peña-López, Rosa González-Rivera, María Fernanda García-Leyva, Mónica Tejeda-Romero, Jorge Cruz‐Rico, Carolina Balderas-Delgado, Guillermo J. Ruíz‐Argüelles, David Gómez‐Almaguer,

Childhood Cancer Survivors' Quality of Life

The COVID-19 pandemic is a colossal challenge for global health; nonetheless, specific subgroups face considerably higher risks for infection and mortality. Among patients with malignant diseases, those with hematologic neoplasms are at a higher risk for poor outcomes. The objective of this study was to register treatment modifications associated with the COVID-19 pandemic and their short-term consequences in Latin America.Multicenter, prospective, observational, cohort study including patients older than 14 years from 14 centers in four countries (Mexico, Peru, Guatemala, and Panama) who had a confirmed diagnosis of acute leukemia, and who were undergoing active treatment since the first COVID-19 case in each country until the cutoff on July 15, 2020.We recruited 635 patients. Treatment modifications because of the COVID-19 pandemic were reported in 40.8% of cases. The main reason for such modifications was logistic issues (55.0%) and the most frequent modification was chemotherapy delay (42.0%). A total of 13.1% patients developed COVID-19 disease, with a mortality of 37.7%. Several factors were identified as independently associated with mortality, including a diagnosis of acute myeloid leukemia (odds ratio 2.38 [95% CI, 1.47 to 3.84]; P < .001), while the use of telemedicine was identified as a protective factor (odds ratio 0.36 [95% CI, 0.18 to 0.82]; P = .014).These results highlight the collateral damage of COVID-19 in oncology patients.