Portal de Periódicos da CAPES

VP50.23: Second trimester ultrasound‐guided placental laterality as predictor of pre‐eclampsia: a systematic review and meta‐analysis

2020; Wiley; Volume: 56; Issue: S1 Linguagem: Inglês

10.1002/uog.23203

1469-0705

M. Puyo‐Quintila, M. Pili‐Lopez,

Assisted Reproductive Technology and Twin Pregnancy

The primary aim of the study is to determine 2nd trimester ultrasound guided placental laterality as predictor of pre-eclampsia. It also aims to identify and appraise published studies on placental laterality and with the development of pre-eclampsia. A comprehensive search was conducted using MEDLINE, PUBMED, Google Scholar, Cochrane Library and Herdin to identify eligible studies between 2010 to 2019. The indexed search terms used were “placental laterality”, pre-eclampsia”, “central placenta”, “lateral placenta” and “placental location”. The search will be limited to published human studies. Eligible studies are prospective studies which will evaluate placental localisation of singleton pregnancy at 18–24 weeks' age of gestation in the development of pre-eclampsia. Nine studies were included in the study. We excluded studies of patients with other risk factors such as chronic hypertension, renal disease, history of smoking, multiple pregnancy, diabetes mellitus, uterine anomalies and placenta previa. We excluded the following types of study: narrative or systematic reviews, retrospective design studies, case report and case series. The statistical analysis will be performed with Revman 5.2 software with p = 0.05 as statistically significant. Data will be presented as a forest plot. A forest plot for comparison of central versus lateral placentation in developing pre-eclampsia based on 7684 subjects is presented. 4044 patients had central placenta, 510 developed pre-eclampsia; while 3,640 subjects had lateral placenta, 571 had pre-eclampsia. There is a difference of 3.07 % which is significant at p = 0.0001 at p = 0.05 level of significance. Pregnant women with lateral placenta are at significant risk for development of pre-eclampsia. Ultrasound is a simple, reliable and cost-effective predictive screening test to determine placental laterality.