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Determination of the Phytochemical Composition and Antioxidant Potential of Eugenia copacabanensis and Myrciaria tenella Leaves (Myrtaceae) Using a Saccharomyces cerevisiae Model

2021; Wiley; Volume: 18; Issue: 6 Linguagem: Inglês

10.1002/cbdv.202100054

1612-1880

Víctor de Carvalho Martins, Liliana Princisval França, Yasmim da Silva Borges Ferreira, Daniele Cabral Pires, Bárbara de Souza Cardoso, Manuela Cristina Pessanha de Araújo Santiago, Sidney Pacheco, Marcelo da Costa Souza, Cristiano Jorge Riger, Ronoel Luiz de Oliveira Godóy, Mário Geraldo de Carvalho,

Essential Oils and Antimicrobial Activity

Abstract Eugenia copacabanensis and Myrciaria tenella are present in restingas of the Atlantic Forest, but little information is available about their chemical and biological potential. In this context, the hexane, dichloromethane, ethyl acetate and butanol fractions from the leaves of methanolic extract were analyzed by GC/MS and HPLC‐DAD and the antioxidant potential was determined by DPPH and ABTS assays and using a Saccharomyces cerevisiae model. Dereplication allowed the identification of 68 compounds, 42 and 41 of which, respectively, are first reported here for E. copacabanensis and M. tenella. In vivo results revealed that the ethyl acetate and butanol fractions showed expressive antioxidant protection in the BY4741 and Δgsh1 strains, with greater impact on glutathione‐deficient cells. With a high diversity of phenolic compounds, these polar fractions of E. copacabanensis and M. tenella leaves are potential protectors against intracellular oxidative stress.