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Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy

2021; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 4 Linguagem: Inglês

10.3390/v13040687

1999-4915

Maria das Graças Costa Alecrim, Melânia Maria Ramos Amorim, Thália Velho Barreto de Araújo, Patrícia Brasil, Elizabeth B. Brickley, Márcia C. Castilho, Bernadete Perez Coêlho, Antônio José Lêdo Alves da Cunha, Geraldo Duarte, Cássia Fernanda Estofolete, Ricardo Queiroz Gurgel, Juliana Herrero-Silva, Cristina Barroso Hofer, Aline de Siqueira Alves Lopes, Celina Maria Turchi Martelli, Adriana Suely de Oliveira Melo, Demócrito de Barros Miranda-Filho, Ulísses Ramos Montarroyos, Maria Elizabeth Lopes Moreira, Marisa Márcia Mussi‐Pinhata, Consuelo Silva de Oliveira, Saulo Duarte Passos, Arnaldo Prata‐Barbosa, Darci Neves dos Santos, Lavínia Schüler‐Faccini, Antônio Augusto Moura da Silva, Isadora Cristina de Siqueira, Patrícia S. Sousa, Marília Dalva Turchi, Ricardo Arraes de Alencar Ximenes, Ana Laura de Sene Amâncio Zara,

Global Maternal and Child Health

Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.