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Will SARS-CoV-2 variants of concern affect the promise of vaccines?

2021; Nature Portfolio; Volume: 21; Issue: 6 Linguagem: Inglês

10.1038/s41577-021-00556-5

1474-1741

Ravindra K. Gupta,

COVID-19 epidemiological studies

Initial optimism regarding the development of COVID-19 vaccines has been tempered by the emergence of new variants of SARS-CoV-2. Will vaccination be able to contain the pandemic? How can we best optimize the limited supplies of vaccines available and what should future COVID-19 vaccines look like? This Comment discusses how the emerging SARS-CoV-2 variants of concern could impact on the hopes of long-term pandemic control through vaccination and the mutations that might be relevant to the design of modified vaccines.