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Maternal death related to COVID‐19: A systematic review and meta‐analysis focused on maternal co‐morbidities and clinical characteristics

2021; Elsevier BV; Volume: 154; Issue: 2 Linguagem: Inglês

10.1002/ijgo.13726

1879-3479

Marco La Verde, Gaetano Riemma, Marco Torella, Stefano Cianci, Fabiana Savoia, Federico Licciardi, S. Scida, Maddalena Morlando, Nicola Colacurci, Pasquale De Franciscis,

Maternal Mental Health During Pregnancy and Postpartum

Besides reducing the quality of obstetric care, the direct impact of COVID-19 on pregnancy and postpartum is uncertain.To evaluate the characteristics of pregnant women who died due to COVID-19.Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021.Studies that compared deceased and survived pregnant women with COVID-19.Relevant data were extracted and tabulated. The primary outcome was maternal co-morbidity.Thirteen studies with 154 deceased patients were included. Obesity doubled the risk of death (relative risk [RR] 2.48, 95% confidence interval [CI] 1.41-4.36, I2 = 0%). No differences were found for gestational diabetes (RR 5.71; 95% CI 0.77-42.44, I2 = 94%) or asthma (RR 2.05, 95% CI 0.81-5.15, I2 = 0%). Overall, at least one severe co-morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77-2.89, I2 = 76%). Admission to intensive care was related to a fivefold increased risk of death (RR 5.09, 95% CI 2.00-12.98, I2 = 56%), with no difference in need for respiratory support (RR 0.53, 95% CI 0.23-1.48, I2 = 95%) or mechanical ventilation (RR 4.34, 95% CI 0.96-19.60, I2 = 58%).COVID-19 with at least one co-morbidity increases risk of intensive care and mortality.