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Deep learning early warning system for embryo culture conditions and embryologist performance in the ART laboratory

2021; Springer Science+Business Media; Volume: 38; Issue: 7 Linguagem: Inglês

10.1007/s10815-021-02198-x

1573-7330

Charles L. Bormann, Carol Lynn Curchoe, Prudhvi Thirumalaraju, Manoj Kumar Kanakasabapathy, Raghav Gupta, Rohan Pooniwala, Hemanth Kandula, Irene Souter, Irene Dimitriadis, Hadi Shafiee,

Assisted Reproductive Technology and Twin Pregnancy

Staff competency is a crucial component of the in vitro fertilization (IVF) laboratory quality management system because it impacts clinical outcomes and informs the key performance indicators (KPIs) used to continuously monitor and assess culture conditions. Contemporary quality control and assurance in the IVF lab can be automated (collect, store, retrieve, and analyze), to elevate quality control and assurance beyond the cursory monthly review. Here we demonstrate that statistical KPI monitoring systems for individual embryologist performance and culture conditions can be detected by artificial intelligence systems to provide systemic, early detection of adverse outcomes, and identify clinically relevant shifts in pregnancy rates, providing critical validation for two statistical process controls proposed in the Vienna Consensus Document; intracytoplasmic sperm injection (ICSI) fertilization rate and day 3 embryo quality.