Portal de Periódicos da CAPES

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

2021; Elsevier BV; Volume: 28; Issue: 5 Linguagem: Inglês

10.1016/j.stem.2021.04.005

1934-5909

Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Helmuth Gehart, Eelco J.P. de Koning, Frédéric P. Lemaigre, Stuart J. Forbes, Weng Chuan Peng, Meritxell Huch, Takanori Takebe, Ludovic Vallier, Hans Clevers, Luc J. W. van der Laan, Bart Spee, Ary Marsee, Floris J.M. Roos, Monique M.A. Verstegen, Hans Clevers, Ludovic Vallier, Takanori Takebe, Meritxell Huch, Weng Chuan Peng, Stuart J. Forbes, Frédéric P. Lemaigre, Eelco J.P. de Koning, Helmuth Gehart, Luc J. W. van der Laan, Bart Spee, Sylvia F. Boj, Pedro M. Baptista, Kerstin Schneeberger, Carol J. Soroka, Markus H. Heim, Sandro Nuciforo, Kenneth S. Zaret, Yoshimasa Saito, Matthias P. Lütolf, Vincenzo Cardinale, Ben Simons, Sven van IJzendoorn, Akihide Kamiya, Hiromi Chikada, Shuyong Wang, Seon Ju Mun, Myung Jin Son, Tamer T. Önder, James L. Boyer, Toshiro Sato, Nikitas Georgakopoulos, André Marcelo Conceição Meneses, Laura Broutier, Luke Boulter, Dominic Grün, Jan N.M. IJzermans, Benedetta Artegiani, Ruben van Boxtel, Ewart Kuijk, Guido Carpino, Gary Peltz, Jesús M. Bañales, Nancy Kwan Man, Luigi Aloia, Nicholas F. LaRusso, Gregory A. George, Casey A. Rimland, George C. Yeoh, Anne Grappin-Botton, Daniel E. Stange, Nicole Prior, Janina E. E. Tirnitz‐Parker, Emma Andersson, Chiara Braconi, Nicholas R. F. Hannan, Wei‐Yu Lu, Stephen C. Strom, Pau Sancho‐Bru, Shinichiro Ogawa, Vincenzo Corbo, Madeline A. Lancaster, Huili Hu, Sabine A. Fuchs, Delilah Hendriks,

Genetic and Kidney Cyst Diseases

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.