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DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

2021; Future Medicine; Volume: 13; Issue: 11 Linguagem: Inglês

10.2217/epi-2021-0006

1750-1911

Beatriz García-Ruiz, Manuel Castro de Moura, Gerard Muntané, Lourdes Martorell, Elena Bosch, Manel Esteller, Erick J. Canales‐Rodríguez, Edith Pomarol‐Clotet, Esther Jiménez, Eduard Vieta, Elisabet Vilella,

Genetics and Neurodevelopmental Disorders

Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.