NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
2021; American Association for the Advancement of Science; Volume: 7; Issue: 19 Linguagem: Inglês
10.1126/sciadv.abf7114
ISSN2375-2548
AutoresPallavi Jain, Anna Dvorkin‐Gheva, Erik Mollen, Lucie Malbeteau, Michael Xie, Fatima Jessa, Piriththiv Dhavarasa, Stephen W. Chung, Kevin R. Brown, Gun Ho Jang, Parth Vora, Faiyaz Notta, Jason Moffat, David W. Hedley, Paul C. Boutros, Bradly G. Wouters, Marianne Koritzinsky,
Tópico(s)ATP Synthase and ATPases Research
ResumoReductive power in the cytosol of pancreatic cancer cells drives a dependency on the endoplasmic reticulum protein PRDX4.
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