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Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease

2021; Elsevier BV; Volume: 236; Linguagem: Inglês

10.1016/j.jpeds.2021.05.023

1097-6833

Ana Barrios-Tascón, Masaru Miura, Sara Domínguez‐Rodríguez, Elisa Fernández-Cooke, Geòrgia Sarquella-Brugada, Alfredo Tagarro, Elisa Fernández-Cooke, Cristina Calvo, Judith Sánchez-Manubens, Jordi Antón, Javier Aracil Santos, Esmeralda Núñez Cuadros, María Luisa Navarro Gómez, David Moreno Pérez, María Martín Cantero Pérez, Esmeralda Nuñez Cuadros Pérez, Begoña Carazo Gallego Pérez, Fernando Sánchez García, Marisol Camacho Lovillo, Renata Marqués, Olaf Neth Laura, Fernández Silveira, Miguel Forte, Ángeles Ortega Montes, Leticia Isabel Martínez Campos, Beatriz Bravo Mancheño, M. Camacho, Antonio F. Medina Claros, Carlos Salido, María Torres Rico, Beatriz Ruiz Sáez, Elena Fernadez de la Puebla Lechuga, Ma José Lirola Cruz, Kety Maya Carrasco, Moisés Rodríguez‐González, Enrique Blanca Jover, José Uberos Fernández, María Mercedes Ibáñez Alcalde, Miguel Lafuente Hidalgo, Lorenzo Jiménez Montañes, Matilde Bustillo Alonso, A. Ayerza Casas, Bárbara Montes Zapico, Carlos Pérez Mendez, Javier Fernández Aracama, Lucía Rodríguez, María Aleida Ibáñez Fernández, Sandra Navarro Campo, Silvia Escribá Bori, María Concepción Mir Perelló, Ma Ángeles de la Fuente Sánchez, Patricia Aparicio García, Carlos Briales, Joaquín Castilla Crespí, María Elena Colino Gil, Nerea Delgado Cabrera, Ana Bello Naranjo, Jesús Poch Páez, Moneyba García Yáñez, Montse González García, Maite Viadero, Beatriz Jiménez Montero, Olga Domínguez García, Begoña Losada Pinedo, Gema Íñigo Martín, Lucía María Escribano Gómez, Antonio Cepillo, Miguel Lillo, María Isabel Buedo, Laura Rey, Elena Urbaneja Rodríguez, Sara Rellán Rodríguez, Teresa Cantero, Beatriz Plata Izquierdo, Luisa Álvarez, Ignacio Oulego‐Erroz, Elena Pérez Santaolalla, Carlos Alcalde Martín, Fernándo Centeno Malfaz, Elena Pérez Gutiérrez, Ma Soledad Jiménez Casso, Fredy Prada, Rosa Bou, E. Iglesias, Joan Calzada, Olga Calavia Garsaball, Marc Tobeña Rue, Gemma Giralt, Zulema Lobato, N. Rius Gordillo, Montserrat Pascual Torres, María Méndez Hernández, Lourdes R. García, Sergio Flores Villar, Silvia Yevenes Ruiz, Laura Minguell Domingo, Anna Ballester, Ana Miralles-Marco, Berta Pujol Soler, Anton Foguet Vidal, Pere Sala, Angelita Serrano Aguiar, José Manuel Siurana Rodríguez, Anna Sangorrin Iranzo, Roser Álvarez Pérez, Paula Ribes Cajas, Pere Genaró i Jornet, Ana Grande Tejada, Cristina Zarallo, Federico Martinón‐Torres, Irene Rivero‐Calle, Antonio Justicia Grande, María López Sousa, Alejandro Souto Vilas, Bernardo López Abel, Elisa de Miguel Esteban, Bibiana Riaño Méndez, Daniel Blázquez‐Gamero, Pablo Rojo Conejo, Carlos Grasa, Belén Toral, Leticia Albert De la Torre, Jaime de Inocencio Arocena, Mar Santos, Rafael Díaz-Delgado de la Peña, Paz Collado Ramos, Teresa Raga, Libertad Latorre, Sara Guillén, Ignacio Callejas Caballero, Luis Prieto, María Fernanda Guzmán Monagas, Isabel López, Sandra Villagrá, Viviana Arreo, Roi Piñeiro Pérez, María de la Parte, Amalia Tamariz-Martes, Marta Llorente, Maria Belén Hernández Rupérez, Henar Rojo Sombrero, Estefanía García Cerro, Irene Maté Cano, Marta Villares Alonso, Marta Pilar Osuna‐Marco, Julia Jensen Veron, Cristina Zarallo Reales, María Dolores Rodríguez Mesa, Santiago Rueda Esteban, José Tomás Ramos Amador, Cristina González Menchén, Ana Belén Jiménez Jiménez, Pilar Galán del Río, Dolores Pérez Campos, Ma Mercedes Bueno, D. Crespo Marcos, Enrique Otheo de Tejada Barásoain, Walter Alberto Sifuentes Giraldo, María Luz Gámir Gámir, María José Cilleruelo Ortega, Agustín López López, Cristina Sánchez Vaquerizo, Ana Isabel Usano Carrasco, Ester Moreno Gómez, Olga Carvajal del Castillo, Beatriz Del Pozo Menéndez, Katie Badillo Navarro, Fernando Baquero, L. Deiros Bronte, Pablo Fernández Fraga, Nieves Domínguez, Beatriz Mercader Rodríguez, Francisco Castro García, Águeda Herrera Chamorro, Paula Alcañiz Rodríguez, Moisés Sorlí García, María Concepción Rex Nicolás, Elena Vera Romero, Patricia Martínez Olorón, Beatriz Rocandio Cilveti, Amaia Berridi, Laura Santos-Díez Vázquez, Olaia Fernández, Inmaculada Calvo, Belén Fernández Tudela, Manuel Oltra Benavent, Marta Dapena Archilés, Franciasco Sanchez Ferrer, César Gavilán, Ignacio Izquierdo Fos, María Isabel Robles, Yolanda Herranz Sánchez, Enrique Villalobos Pinto, Daniel Clemente, Stella Pie, Manuel Marrero Calvo, José María Olmos García,

Cardiac Structural Anomalies and Repair

To evaluate electrocardiogram markers to predict coronary involvement in patients with Kawasaki disease by assessing measures of ventricular repolarization parameters on the 12-lead electrocardiogram.This cross-sectional study included 180 Spanish and Japanese patients ≤14 years of age with Kawasaki disease, with or without coronary involvement, from 2011 to 2016. We manually measured the Tp-Te/QT ratio and QTc interval (with Bazett's formula) in 12-lead electrocardiogram in the acute and recovery period and explored their potential association with coronary involvement.No association was found between Tp-Te/QT ratio obtained manually in V5 and V6 leads and coronary involvement in the acute (V5:0.25 [IQR, 0.21-0.27] vs 0.25 [IQR, 0.20-0.27], P = .80; V6:0.24 [IQR, 0.21-0.27] vs 0.25 [IQR, 0.20-0.27], P = .86) or the recovery (V5: 0.23 [IQR, 0.20-0.25] vs 0.23 [IQR, 0.19-0.25], P = .68; V6: 0.23 [IQR, 0.20-0.25] vs 0.23 [IQR, 0.17-0.25], P = .50) period. By contrast, QTc in V5 and V6 was significantly lower in patients with Kawasaki disease and coronary involvement in the acute period (V5: 378 ms [IQR, 364-395 ms] vs 390 ms [IQR, 371-411 ms], P = .04; V6: 377 ms [IQR, 364-392 ms] vs 390 ms [IQR, 371-410 ms], P = .01). A QTc interval of <385 ms in lead V6 was associated with a 2.5-fold increased risk of coronary involvement (OR, 2.5; 95% CI, 1.2-5.3; P = .02).Manually measured QTc interval may be a marker of coronary disease in the acute period of Kawasaki disease.