Chemogenetic engineering of nitrobindin toward an artificial epoxygenase
2021; Royal Society of Chemistry; Volume: 11; Issue: 13 Linguagem: Inglês
10.1039/d1cy00609f
ISSN2044-4761
AutoresDaniel F. Sauer, Malte Wittwer, Ulrich Markel, Alexander Minges, Markus Spiertz, Johannes Schiffels, Mehdi D. Davari, Georg Groth, Jun Okuda, Ulrich Schwaneberg,
Tópico(s)Microbial metabolism and enzyme function
ResumoChemogenetic engineering turned the heme protein nitrobindin into an artificial epoxygenase: MnPPIX was introduced and subsequent protein engineering increased the activity in the epoxidation of styrene derivatives by overall 7-fold.
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