Produção Nacional
Revisado por pares
No strong HLA association with MOG antibody disease in the UK population
2021; Wiley; Volume: 8; Issue: 7 Linguagem: Inglês
10.1002/acn3.51378
ISSN2328-9503
AutoresMelissa Grant‐Peters, Giordani Rodrigues dos Passos, Hing‐Yuen Yeung, Anu Jacob, Saif Huda, Maria Isabel Leite, Calliope A. Dendrou, Jacqueline Palace,
Tópico(s)Cell Adhesion Molecules Research
ResumoAbstract Improvements in assays for detecting serum antibodies against myelin oligodendrocyte glycoprotein (MOG) have led to the appreciation of MOG‐antibody‐associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti‐MOG antibody generation. A weak protective association of HLA‐C*03:04 was observed (OR = 0.26, 95% CI = 0.10‐0.71, p c = 0.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology.
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