Produção Nacional
Revisado por pares
Clinical outcomes and quality of life of COVID-19 survivors: A follow-up of 3 months post hospital discharge
2021; Elsevier BV; Volume: 184; Linguagem: Inglês
10.1016/j.rmed.2021.106453
ISSN1532-3064
AutoresBeatriz Costa Todt, Cláudia Szlejf, Etienne Duim, Alana O.M. Linhares, Diogo Kogiso, Gabriela Varela, Bruna A Campos, Cristina Mara Baghelli Fonseca, Leonardo E. Polesso, Ingra N.S. Bordon, Bruno T. Cabral, Victor L P Amorim, Felipe M T Piza, Luiza Helena Degani‐Costa,
Tópico(s)COVID-19 and Mental Health
ResumoHighlights•COVID-19 admission is associated with persistent clinical and mental health problems.•Dyspnoea persists up to 3 months following hospital discharge in many patients.•HRQoL is significantly worsened up to 3 months following hospital discharge.•Pain/discomfort and anxiety/depression were the most impacted domains of HRQoL.•Female sex and intensive care requirement were associated with worsening of HRQoL.AbstractBackgroundOver 66 million people worldwide have been diagnosed with COVID-19. Therefore, understanding their clinical evolution beyond hospital discharge is essential not only from an individual standpoint, but from a populational level.ObjectivesOur primary aim was to assess the impact of COVID-19 on health-related quality of life (HRQoL) 3 months after hospital discharge. Additionally, we screened for anxiety and depression and assessed important clinical outcomes.MethodsThis was a single-center cohort study performed in Sao Paulo (Brazil), in which participants were contacted by telephone to answer a short survey. EQ-5D-3L was used to assess HRQoL and clinical data from patients' index admission were retrieved from medical records.ResultsWe contacted 251 participants (59.8% males, mean age 53 years old), 69.7% of which had presented with severe COVID-19. At 3 months of follow-up, 6 patients had died, 51 (20.3%) had visited the emergency department again and 17 (6.8%) had been readmitted to hospital. Seventy patients (27.9%) persisted with increased dyspnoea and 81 had a positive screening for anxiety/depression. Similarly, patients reported an overall worsening of EQ-5D-3L single summary index at 3 months compared to before the onset of COVID-19 symptoms (0.8012 (0.7368 – 1.0) vs. 1.0(0.7368 – 1.0), p < 0.001). This affected all 5 domains, but especially pain/discomfort and anxiety/depression. Only female sex and intensive care requirement were independently associated with worsening of HRQoL.ConclusionPatients hospitalized for COVID-19 frequently face persistent clinical and mental health problems up to 3 months following hospital discharge, with significant impact on patients' HRQoL.
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