Produção Nacional
Revisado por pares
Quick synthesis of isatin-derived knoevenagel adducts using only eco-friendly solvent
2021; Elsevier BV; Volume: 3; Linguagem: Inglês
10.1016/j.rechem.2021.100135
ISSN2211-7156
AutoresJoão Marcos Gomes de Oliveira Ferreira, Girlyanderson Araújo da Silva, Maísa Cavalcanti Coelho, Cláudio Gabriel Lima-Júnior, Juliana A. Vale,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoA variety of knoevenagel compounds from isatin were synthesized using an eco-friendly methodology. It was used only the binary solvent ethanol: water (3:7 v/v) without the presence of metal catalyst what enabled the reaction between different isatins with malononitrile in a quick reaction time of 2–5 min and isolated yields 80–96%. When cyanoesters were used as methylene actives, the reactions were longer and the knoenevagel products were obtained 79–92% isolated yields.
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