VCAM-1 as a predictor biomarker in cardiovascular disease
2021; Elsevier BV; Volume: 1867; Issue: 9 Linguagem: Inglês
10.1016/j.bbadis.2021.166170
ISSN1879-260X
AutoresMayarling Francisca Troncoso, Jafet Ortiz‐Quintero, Valeria Garrido‐Moreno, Fernanda Sanhueza‐Olivares, Alejandra Guerrero‐Moncayo, Mario Chiong, Pablo Castro, Lorena Garcı́a, Luigi Gabrielli, Ramón Corbalán, Luis Garrido‐Olivares, Sergio Lavandero,
Tópico(s)Cardiac Fibrosis and Remodeling
ResumoThe vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically participates in the adhesion and transmigration of leukocytes to the interstitium during inflammation. VCAM-1 expression, together with soluble VCAM-1 (sVCAM-1) induced by the shedding of VCAM-1 by metalloproteinases, have been proposed as biomarkers in immunological diseases, cancer, autoimmune myocarditis, and as predictors of mortality and morbidity in patients with chronic heart failure (HF), endothelial injury in patients with coronary artery disease, and arrhythmias. This revision aims to discuss the role of sVCAM-1 as a biomarker to predict the occurrence, development, and preservation of cardiovascular disease.
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