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Trace level electrochemical detection of mesalazine in human urine sample using poly (N-Vinyl)-2-Pyrrolidone capped Bi-EDTA complex sheets incorporated with ultrasonically exfoliated graphene oxide

2021; Elsevier BV; Volume: 122; Linguagem: Inglês

10.1016/j.jtice.2021.04.058

1876-1089

Narasimha Murthy Umesh, Antolin Jesila Jesu Amalraj, Sea‐Fue Wang,

Analytical Chemistry and Sensors

Trace level detection of drugs and hazardous analytes is more critical in electrochemical sensor. In this work, a simple sonochemical-assisted synthesis of Bismuth-EDTA complex/GO flakes was achieved and was developed to analyze mesalazine (MSA) sensing. The 3D hollow bricks were obtained for the Bi-EDTA complex without PVP. Surprisingly, PVP influenced the formation of broken glass-like structured for PVP with Bi-EDTA complex. Bi-EDTA complex modified GCE was developed to determine the role of PVP and its activity in electrochemical sensors. The results obtained by modifying the electrode Bi-EDTA complex with PVP showed good electrochemical performance compared to bare and other controls like GO and Bi-EDTA complex without PVP. The synergetic effect and high electroactive sites of Bi-EDTA complex/GO modified sensor implied low LOD (0.55 nM) and wide linear range from 0.005–585 µM. Furthermore, Bi-EDTA complex/GO showed an excellent selectivity in sensing MSA. Moreover, the Bi-EDTA complex exhibits advantages such as good stability, reproducibility, and repeatability. The modified Bi-EDTA complex/GCE sensor has been practically done to determine trace levels of MSA in human urine samples containing mesalamine tablets with satisfactory results.