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The influence of early exposure to methylphenidate on addiction-related behaviors in mice

2021; Elsevier BV; Volume: 206; Linguagem: Inglês

10.1016/j.pbb.2021.173208

1873-5177

Daniella Oliveira-Campos, Henrique Sousa Reis, Matheus Libarino-Santos, Elisangela Gouveia Cata-Preta, Thaísa Barros dos Santos, Alexia Anjos-Santos, Thaynara Silva Oliveira, A.C. Brito, Camilla L. Patti, E.A.V. Marinho, Alexandre Justo de Oliveira Lima,

Memory and Neural Mechanisms

Methylphenidate (MET) has a putative cognitive enhancer effect that has led adolescents and young adults to increase and indiscriminate its use aiming to ameliorate their productivity. However, the impacts of MET on addiction-related behaviors, emotional levels, and cognition are still not fully understood. To investigate the influence of chronic treatment with MET during adolescence on addiction-like behaviors, memory, and anxiety in adult mice. Thirty-day-old female mice received i.p. 10 mg/kg MET or Veh injections for 10 consecutive days. Forty days after the treatment (mice were 70-days-old), animals were submitted to the behavioral evaluation under the effects of MET, which included: MET-induced conditioned place preference (CPP), behavioral sensitization, and plus-maze discriminative avoidance task. Pre-exposure to MET during adolescence promoted an early expression of CPP and also facilitated the development of MET-induced behavioral sensitization during adulthood. These addictive-like behaviors were accompanied by anxiogenic effects of MET but not by any memory-enhancing effect. We demonstrated that exposure to MET during adolescence can increase the vulnerability to addiction-like behaviors and anxiety during adulthood. Our results reinforce the necessity of a more efficient system to control MET indiscriminate use, thus avoiding its potential tardive addictive effects.