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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma

2021; Taylor & Francis; Volume: 29; Issue: 3 Linguagem: Inglês

10.1080/09273948.2021.1878233

ISSN

1744-5078

Autores

Denise Carbonell, Sarakshi Mahajan, Soon‐Phaik Chee, Bianka Sobolewska, Rupesh Agrawal, Tanja Bülow, Vishali Gupta, Nicholas P. Jones, Massimo Accorinti, Mamta Agarwal, Tracy T. Batchelor, Jyotirmay Biswas, Luca Cimino, Ninette H. tenDam-van Loon, Alejandra de‐la‐Torre, Shahar Frenkel, Jacob Pe’er, Michal Kramer, Elisabetta Miserocchi, Manabu Mochizuki, Thomas Neß, James T. Rosenbaum, H. Nida Sen, Michael Simion, H. Sitter, Daniel V. Vasconcelos-Santos, Zohar Habot‐Wilner, Sarah E. Coupland, José S. Pulido, Justine R. Smith, Jennifer E. Thorne, Manfred Zierhut,

Tópico(s)

Viral-associated cancers and disorders

Resumo

Purpose To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL).Methods Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi 2), items of the questionnaire not reaching consensus (75% agreement) were discussed to finalize the recommendations.Results Presenting symptoms include floaters and painless loss of vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in the outer retina. Other findings include retinal lesions with "leopard-skin" appearance and retinal pigment epithelium atrophy. Severe vitreous infiltration without macular edema is the most likely presentation. Diagnostic vitrectomy should be performed. Systemic corticosteroid should be discontinued at least 2 weeks before surgery. An interleukin (IL)-10:IL-6 ratio > 1, positive mutation for the myeloid differentiation primary response 88 gene and monoclonality are indicators of VRL. Multi-modal imaging (optical coherence tomography, fundus autofluorescence) are recommended.Conclusions A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL.

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