Dithionite-Involved Multicomponent Coupling for Alkenyl and Alkyl Tertiary Sulfones
2021; American Chemical Society; Volume: 23; Issue: 12 Linguagem: Inglês
10.1021/acs.orglett.1c01393
ISSN1523-7060
AutoresYaping Li, Ming Wang, Xuefeng Jiang,
Tópico(s)Chemical Synthesis and Reactions
ResumoA dithionite-involved multicomponent reaction of redox-active esters and alkenes/alkynes is comprehensively achieved for the construction of alkyl and alkenyl tertiary sulfones. The industrial feedstock sodium dithionite is employed as a sulfur dioxide surrogate and a single-electron reductant to initiate the decarboxylation of redox-active esters. Mechanistic studies further indicated that the transformation underwent a proton trapping process, which was different from the traditional radical trapping pathway.
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