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Parkinsonism as a Sequela of SARS‐CoV‐2 Infection: Pure Hypoxic Injury or Additional COVID‐19‐Related Response?

2021; Wiley; Volume: 36; Issue: 7 Linguagem: Inglês

10.1002/mds.28656

1531-8257

Conor Fearon, David J. Mikulis, Anthony E. Lang,

Neurological and metabolic disorders

The role that SARS-CoV-2 infection could play in causing post-COVID-19-parkinsonism (even to the point of creating a modern pandemic of post-infectious parkinsonism) has gained significant traction since the virus first emerged.1, 2 One year later, however, there have been only five published cases of parkinsonism occurring in the setting of COVID-19.3-7 Although the clinical features of one of these cases is highly suggestive of a parainfectious/inflammatory etiology,4 many of the other presentations may merely represent an infectious stressor unmasking prodromal Parkinson's disease.7, 8 We present an alternative cause of parkinsonism following SARS-CoV-2 infection. A 46-year-old man presented with fever, dyspnea, and cough. He was diagnosed with COVID-19 and rapidly became hypoxemic, developing acute respiratory distress syndrome necessitating intubation and ventilation. He became hypotensive requiring pressor support and his respiratory function declined. His intensive care unit stay was prolonged and complicated by acute renal failure requiring dialysis and disseminated intravascular coagulation (DIC). When finally extubated, he exhibited marked hypophonia and bradykinesia. One year later, he demonstrates severe residual parkinsonism which has been unresponsive to levodopa (450 mg/day). Examination reveals frequent yawning, severe hypophonia, hypomimia, asymmetric rigidity and bradykinesia, freezing of gait, and postural instability (Video S1). He has a positive grasp reflex with an impaired Luria test. Computed tomograpy (CT) brain scan post-extubation demonstrated edema in the globus pallidus bilaterally and deep cerebellar nuclei containing small hemorrhagic foci (Fig. 1A,B). Magnetic resonance imaging (MRI) brain scan 3 weeks later confirmed these focal findings (Fig. 1C,D). Repeat MRI brain scan 3 weeks subsequently showed resolution of edema with tissue loss consisting of atrophy in the globus pallidus and severe tissue loss in the dentate nuclei. Susceptibility-weighted imaging in these nuclei confirmed iron deposition from hemorrhage in these structures (Fig. 1E–J). Diffuse white matter ischemic/hemorrhagic changes were not present. These imaging findings support a devastating but focal process affecting the globus pallidus and dentate nuclei with hemorrhage (particularly prominent in the dentate nuclei) and gliosis. Isolated basal ganglia involvement without diffuse cortical involvement is rare in hypoxic–ischemic injury but occurs more frequently due to respiratory or hypovolemic-shock mechanisms.9 Another reported COVID-19 case with similar pallidal imaging changes presented with refractory hypoxemia requiring intubation and developed shock, DIC, and acute renal failure.10 MRI revealed symmetric T2 prolongation in the bilateral globus pallidus as well as the hippocampi and substantia nigra but no dentate abnormalities. The authors concluded that hypoxic–ischemic injury was the likely etiology but no parkinsonism was reported. Disseminated cerebral microhemorrhages, distinct from the changes evident in our patient, are well-described sequelae of critical illness.11 However, microhemorrhages also result from SARS-CoV-2-induced endotheliitis and have been observed in the basal ganglia (but not dentate nuclei) in post-mortem COVID-19 studies.12 A recent neuropathological study of 41 patients who died from COVID-19 found hypoxic/ischemic changes in all brains, many of which were hemorrhagic.13 These findings were focal in 22% of the cases. In addition, microglial nodules and neuronophagia were seen in multiple areas, including the deep cerebellar nuclei. No evidence of direct invasion by SARS-CoV-2 was seen. Although the radiological and clinical features in our case could be attributed to hypoxia alone, it is possible that other mechanisms including cytokine-related neuroinflammation, microglial activation, endothelial dysfunction, and megakaryocyte-mediated hemodynamic changes14 resulting from systemic SARS-CoV-2 infection may have contributed synergistically to our patient's presentation. Indeed, the hemorrhagic dentate changes, which are distinctly unusual for isolated hypoxia,9 suggest the possibility of additional contributing pathophysiological mechanisms. This case highlights an important alternative, albeit poorly understood, cause of COVID-19-associated parkinsonism, distinct from unmasking of pre-existing Parkinson's disease or a form of yet unproven post-infectious parkinsonism. Given the degree of respiratory compromise and "silent hypoxemia" which may accompany COVID-19, as well as potential virus-specific endothelial mechanisms, this may represent an equally, if not more important cause of parkinsonism that requires further careful documentation and study. C.F. and D.J.M. wrote the first draft and subsequent modifications based on A.E.L. supervision and feedback. C.F. is the recipient of an Edmond J. Safra Fellowship in Movement Disorders via the Michael J. Fox Foundation. A.E.L. has acted as a consultant for Abbvie, Acorda, AFFiRis, Biogen, Denali, Janssen, Intracellular, Kallyope, Lundbeck, Paladin, Retrophin, Roche, Sun Pharma, Theravance, and Corticobasal Degeneration Solutions; has served on advisory boards for Jazz Pharma, PhotoPharmics, and Sunovion; has received honoraria from Sun Pharma, AbbVie, Sunovion, American Academy of Neurology, and the International Parkinson and Movement Disorder Society; has received royalties from Elsevier, Saunders, Wiley-Blackwell, Johns Hopkins Press, and Cambridge University Press; and has been a recipient of grants from Brain Canada, Canadian Institutes of Health Research, Corticobasal Degeneration Solutions, Edmond J. Safra Philanthropic Foundation, Michael J. Fox Foundation, the Ontario Brain Institute, Parkinson Foundation, Parkinson Canada, and W. Garfield Weston Foundation. Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Video S1 Patient demonstrates severe hypophonia, asymmetric bradykinesia (worse on left), impaired Luria test, reduced arm swing, reduced step height, freezing of gait on turning, and postural instability. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.