Visible-Light Photoredox Catalyzed Dehydrogenative Synthesis of Allylic Carboxylates from Styrenes
2021; American Chemical Society; Volume: 23; Issue: 11 Linguagem: Inglês
10.1021/acs.orglett.1c01375
ISSN1523-7060
AutoresYang Liu, Simone Battaglioli, Lorenzo Lombardi, Arianna Menichetti, Giovanni Valenti, Marco Montalti, Marco Bandini,
Tópico(s)Sulfur-Based Synthesis Techniques
ResumoThe visible-light photoredox/[Co(III)] cocatalyzed dehydrogenative functionalization of cyclic and acyclic styryl derivatives with carboxylic acids is documented. The methodology enables the chemo- and regioselective allylic functionalization of styryl compounds, leading to allylic carboxylates (32 examples) under stoichiometric acceptorless conditions. Intermolecular as well as intramolecular variants are documented in high yields (up to 82%). A mechanistic rationale is also proposed on the basis of a combined experimental and spectroscopic investigation.
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