Produção Nacional
Revisado por pares
Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis
2021; Elsevier BV; Volume: 154; Linguagem: Inglês
10.1016/j.fct.2021.112287
ISSN1873-6351
AutoresMariana Araújo Vieira do Carmo, Marina Fidelis, Pollyanna Francielli de Oliveira, Lais Quelen Feitoza, Marcos José Marques, Eric Batista Ferreira, Won Young Oh, Fereidoon Shahidi, Jarkko Hellström, Leonardo Augusto de Almeida, Rômulo Dias Novaes, Daniel Granato, Luciana Azevedo,
Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoSince dietary factors are thought to be responsible for high colon cancer risk, we investigated the chemopreventive effect of jabuticaba seed extract (LJE) by administering yogurt with or without LJE against 1,2 dimethyl hydrazine (DMH)-induced colon carcinogenesis in rats. Results showed that LJE contained a total phenolic content of 57.16 g/100 g of seed extract in which 7.67 and 10.09 g/100 g represented total flavonoids and ellagitannins, respectively. LJE protected DNA and human LDL against induced in vitro oxidation, which was associated with the ellagitannin content and with the free-radical scavenging and reducing capacities. LJE alone had a non-clastogenicity/aneugenicity property, but in combination with cisplatin, it enhanced the chromosome aberrations in cancer cells. In colon cancer-induced rats, yogurt with or without LJE caused a reduction in pro-inflammatory parameters, decreased the RNA expression of antiapoptotic cytokines and increased the expression of proapoptotic cytokines. Moreover, LJE attenuated colon cancer initiation and progression by decreasing aberrant crypt foci and LJE recovered the gut microbiome. Together, this evidence suggests that LJE provides chemopreventive protection against colon cancer development by reducing inflammation and increasing proapoptotic pathways.
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