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Genomic characterization and Epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

2021; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2021.06.02.21258076

Mahesh Shanker Dhar, Robin Marwal, Venkatraman Radhakrishnan, Kalaiarasan Ponnusamy, Bani Jolly, Rahul C. Bhoyar, Viren Sardana, Salwa Naushin, Mercy Rophina, Thomas A. Mellan, Swapnil Mishra, Charles Whittaker, Saman Fatihi, Meena Datta, Priyanka Singh, Uma Sharma, Rajat Ujjainiya, Nitin Batheja, Mohit Kumar Divakar, Manoj Kumar Singh, Mohamed Imran, Vigneshwar Senthivel, Ranjeet Maurya, Neha Jha, Priyanka Mehta, A Vivekanand, Pooja Sharma, V. R. Arvinden, Urmila Chaudhary, Namita Soni, Lipi Thukral, Seth Flaxman, Samir Bhatt, Rajesh Pandey, Debasis Dash, Mohammed Faruq, Hemlata Lall, Hema Gogia, Preeti Madan, Sanket Kulkarni, Himanshu Chauhan, Shantanu Sengupta, Sandhya Kabra, Ravindra K. Gupta, Sujeet Kumar Singh, Anurag Agrawal, Partha Rakshit,

COVID-19 Clinical Research Studies

Abstract Delhi, the national capital of India, has experienced multiple SARS-CoV-2 outbreaks in 2020 and reached a population seropositivity of over 50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant B.1.617.2 (Delta) replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and partial reduction of immunity elicited by prior infection (median estimates; ×1.5-fold, 20% reduction). Seropositivity of an employee and family cohort increased from 42% to 86% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi. One-Sentence Summary Delhi experienced an overwhelming surge of COVID-19 cases and fatalities peaking in May 2021 as the highly transmissible and immune evasive Delta variant replaced the Alpha variant.