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SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

2021; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 6 Linguagem: Inglês

10.3390/nano11061394

2079-4991

Elena Zavyalova, Oganes Ambartsumyan, Gleb Zhdanov, Dmitry A. Gribanyov, Vladimir А. Gushchin, Artem P. Tkachuk, Елена В. Рудакова, Maria A. Nikiforova, Nadezhda A. Kuznetsova, Liubov I. Popova, Bakhtiyar I. Verdiev, Artem G. Alatyrev, Burtseva Ei, Anna V. Ignatieva, Anna A. Iliukhina, Inna V. Dolzhikova, Alexander M. Arutyunyan, Alexandra Gambaryan, В. И. Кукушкин,

Biosensors and Analytical Detection

During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.