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The possible benefits of vitamin D in COVID-19

2021; Elsevier BV; Volume: 91-92; Linguagem: Inglês

10.1016/j.nut.2021.111356

1873-1244

Danilo Társio Mota Brito, Luiza Helena Ribeiro, Carla Daltro, Roberto de Barros Silva,

COVID-19 Clinical Research Studies

Molecular studies have demonstrated the importance of the exacerbated immune response to SARS-CoV-2 infection, called the cytokine storm, in more severe COVID-19. The pathophysiology is complex and involves several homeostatic factors; among them, a deficit of vitamin D draws attention because of its high frequency in the population. Some evidence suggests that people with low serum vitamin D levels have worse outcomes, often requiring intensive care. This review analyzed the studies available in the global literature addressing the benefits of vitamin D in COVID-19, relating serum levels to the severity of the disease, and indicating vitamin D as a possible prophylactic and therapy in infection.