Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know
2021; Elsevier BV; Volume: 138; Issue: 4 Linguagem: Inglês
10.1182/blood.2021012152
ISSN1528-0020
AutoresGowthami M. Arepally, Thomas L. Ortel,
Tópico(s)Blood groups and transfusion
ResumoThe development of vaccines to fight COVID-19 has been a remarkable medical achievement. However, this global immunization effort has been complicated by a rare vaccine-related outcome characterized by thrombocytopenia and thrombosis in association with platelet-activating anti-platelet factor 4 antibodies. In this Spotlight, we will discuss the recently described complication of vaccine-induced immune thrombotic thrombocytopenia (VITT) occurring in response to certain COVID-19 vaccines. Although information about this clinical condition is rapidly evolving, we will summarize our current understanding of VITT.
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