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Association of 2D Perfusion Angiography and Wound Healing Rate in Combined Femoro-popliteal and Below-the-Knee Lesions in Ischemic Patients Undergoing Isolated Femoro-popliteal Endovascular Revascularization

2021; SAGE Publishing; Volume: 22; Issue: 3 Linguagem: Inglês

10.1177/15347346211020269

1552-6941

Nicola Troisi, Stefano Michelagnoli, Simone Panci, Sara Bacchi, Daniela Incerti, Luigi Lo Vecchio, G Dedola, Emiliano Chisci,

Acute Ischemic Stroke Management

The aim of this study was to demonstrate the association between 2-dimensional (2D) perfusion angiography and wound healing rate in patients with combined femoro-popliteal and below-the-knee lesions in critical limb-threatening ischemia (CLTI) and foot wounds undergoing isolated femoro-popliteal endovascular revascularization. Between January and June 2019, 24 patients with multilevel CLTI and foot wounds underwent isolated femoro-popliteal endovascular revascularization. In all of them, an assessment of foot perfusion by 2D perfusion angiography was performed. To evaluate the foot perfusion, a region of interest was identified, and time–density curves were calculated. Changes of the overall time–density curves were evaluated together with transcutaneous oximetry (TcPO 2 ) using bivariate correlation (Pearson correlation coefficient) and associated with 6-month wound healing. The mean increase of time–density curves was 212.2% (range from +9.8% to +1984.9%) and the mean increase of TcPO 2 was 116.4% (range from −4.7% to 485.7%). No significant association between time–density curves and TcPO 2 values (Pearson correlation coefficient: −0.24) was observed ( P = .3). At 6 months, wound healing occurred in 15 of 24 (62.5%) patients. In conclusion, this preliminary experience confirmed that 2D perfusion angiography associates with wound healing rate in CLTI patients with ischemic foot wounds and combined femoro-popliteal and below-the-knee lesions who are undergoing isolated femoro-popliteal endovascular revascularization. No association between time–density curves and TcPO 2 values was observed.