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Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and Gd@C82

2021; Multidisciplinary Digital Publishing Institute; Volume: 22; Issue: 11 Linguagem: Inglês

10.3390/ijms22115838

1661-6596

Ivan V. Mikheev, Madina M. Sozarukova, D. Yu. Izmailov, Ivan E. Kareev, Elena V. Proskurnina, Мikhail А. Proskurnin,

Polymer Nanocomposite Synthesis and Irradiation

The antioxidant potential (capacity and activity) of aqueous fullerene dispersions (AFD) of non-functionalized C60, C70, and Gd@C82 endofullerene (in micromolar concentration range) was estimated based on chemiluminescence measurements of the model of luminol and generation of organic radicals by 2,2′-azobis(2-amidinopropane) dihydrochloride (ABAP). The antioxidant capacity was estimated by the TRAP method, from the concentration of half-suppression, and from the suppression area in the initial period. All three approaches agree and show that the antioxidant capacity of AFDs increased in the order Gd@C82 < C70 < C60. Mathematical modeling of the long-term kinetics data was used for antioxidant activity estimation. The effect of C60 and C70 is found to be quenching of the excited product of luminol with ABAP-generated radical and not an actual antioxidant effect; quenching constants differ insignificantly. Apart from quenching with a similar constant, the AFD of Gd@C82 exhibits actual antioxidant action. The antioxidant activity in Gd@C82 is 300-fold higher than quenching constants.