Copper-Catalyzed Vicinal Cyano-, Thiocyano-, and Chlorophosphorylation of Alkynes: A Phosphinoyl Radical-Initiated Approach for Difunctionalized Alkenes
2021; American Chemical Society; Volume: 23; Issue: 11 Linguagem: Inglês
10.1021/acs.orglett.1c01286
ISSN1523-7060
AutoresZe‐Kun Tao, Chengkun Li, Jian‐An Li, Adedamola Shoberu, Wei Zhang, Jian‐Ping Zou,
Tópico(s)Synthesis and Catalytic Reactions
ResumoA copper-catalyzed difunctional cyano-, thiocyano-, and chlorophosphorylation reaction of alkynes with P(O)–H compounds and coupling partners (TBACN, TMSNCS, TMSCl) is described. The reaction introduces versatile groups (−P(O)R2 and −CN, −SCN, or −Cl) to form tri- and tetrasubstituted alkenyl phosphine oxides/phosphonates regio- and stereoselectively.
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