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BIBTEX RIS

Role of neutrophil-lymphocyte ratio as a predictive factor of glioma tumor grade: A systematic review

2021; Elsevier BV; Volume: 163; Linguagem: Inglês

10.1016/j.critrevonc.2021.103372

1879-0461

Alexandra Gomes dos Santos, Rodolfo Figueiredo de Carvalho, Artur Nóbrega Lima Rodrigues de Morais, Tamires Martins Silva, Victor Matheus Ribeiro Baylão, Mayara Azevedo, Adilson de Oliveira,

Bone and Joint Diseases

Gliomas are the main type of intra-axial primary brain tumors. We performed a systematic review of studies on the neutrophil-to-lymphocyte ratio (NLR) and its role in the prognosis of patients with gliomas. An English-language literature-based search, using the PubMed and Biblioteca Virtual em Saúde databases, was conducted for papers published until May 2, 2020. The quality of the selected articles was stratified using the Newcastle-Ottawa scale’s criteria. We found 137 publications for a query string. After applying the inclusion criteria, 13 articles were selected. Seven studies assessed overall survival and found high NLR values associated with poor overall survival. Six studies approached the issue of tumor grading and differential diagnosis and demonstrated that patients with high NLR values were diagnosed with high-grade gliomas. NLR is a low-cost method and an effective prognostic factor associated with tumor grading and OS in patients with gliomas.