Portal de Periódicos da CAPES

The impact of COVID-19 pandemic on psoriasis patients, and their immunosuppressive treatment: a cross-sectional multicenter study from Turkey

2021; Informa; Volume: 33; Issue: 4 Linguagem: Inglês

10.1080/09546634.2021.1927947

1471-1753

Selda Pelin Kartal, Gökçen Çelik, Oğuz Yılmaz, Eda Öksüm Solak, Büşra Demirbağ Gül, Tuba Kevser Üstünbaş, Melis Gönülal, Sevim Baysak, Esma İnan Yüksel, Begüm Ünlü, Münevver Güven, Ali Doğan Bozdağ, Gökhan Çınar, Selim Kartal, Murat Borlu, Müge Güler Özden, Burhan Engın, Server Serdaroğlu, Didem Didar Balcı, Bilal Doğan, Demet Çiçek, Ayça Cordan Yazıcı, Sema Aytekin, Neslihan Şendur, Hayriye Sarıcaoğlu, Nida Kaçar, Asena Çiğdem Doğramacı, Levent Dönmez, Erkan Alpsoy,

COVID-19 and healthcare impacts

Immunosuppressive therapy has been a great concern during the pandemic. This study aimed to evaluate the pandemic's impact on psoriasis patients treated with immunosuppressive drugs.The multicenter study was conducted in 14 tertiary dermatology centers. Demographic data, treatment status, disease course, and cases of COVID-19 were evaluated in patients with psoriasis using the immunosuppressive treatment.Of 1827 patients included, the drug adherence rate was 68.2%. Those receiving anti-interleukin (anti-IL) drugs were more likely to continue treatment than patients receiving conventional drugs (OR = 1.50, 95% CI, 1.181-1.895, p = .001). Disease worsening rate was 24.2% and drug dose reduction increased this rate 3.26 and drug withdrawal 8.71 times. Receiving anti-TNF or anti-IL drugs was associated with less disease worsening compared to conventional drugs (p = .038, p = .032; respectively). Drug withdrawal causes were 'unable to come' (39.6%), 'COVID concern' (25.3%), and 'physician's and patient's co-decision' (17.4%). Four patients had COVID-19 infection with mild symptoms. The incidence was 0.0022% while it was 0.0025% in the general population.Our study shows that psoriasis patients using systemic immunosuppressive do not have a higher, but even lower COVID-19 risk than the general population, and treatment compliance with biological drugs is higher.