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Libidibia ferrea extract as a promising antidiabetic agent: characterization, pre-clinical analysis and development of pharmaceutical dosage forms / Extrato de Libidibia ferrea como um promissor agente antidiabético: caracterização, análise pré-clínica e desenvolvimento de formas de dosagem farmacêutica

2021; Brazilian Journal of Development; Volume: 7; Issue: 4 Linguagem: Inglês

10.34117/bjdv7n4-699

2525-8761

Maria Joanellys dos Santos Lima, Karolynne Rodrigues de Melo, Victor de Albuquerque Wanderley Sales, Myla Lôbo de Souza, Emerson de Oliveira Silva, Wyndly Daniel Cardoso Gaião, Pedró José Rolim Neto, Maria Bernadete de Sousa Maia, Ivone Antônia de Souza, Rosali Maria Ferreira da Silva,

Ginkgo biloba and Cashew Applications

The present work aimed at developing pharmaceutical dosage forms based on the dry bark extract of Libidibia ferrea for the treatment of diabetes mellitus . The physicochemical characterization of the plant raw material, extractive solution and dry extract obtained by freeze drying were carried out. Effervescent granules, oral solution and tablets from the dry extract were developed and subjected to the recommended quality control tests. All materials presented standardized values after physical-chemical characterization. The presence of several secondary compounds was confirmed, and the content of the tannins was determined. The extract did not present acute toxicity in the in vivo experiment and provided an increase in glucose uptake in the in vitro study. The developed formulations complied with previously established values for quality control. The results show the safety and efficacy of the developed products, may being promising options in the treatment of diabetes mellitus .