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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

2021; Cell Press; Volume: 29; Issue: 7 Linguagem: Inglês

10.1016/j.chom.2021.05.010

1934-6069

Alba Grifoni, John Sidney, Randi Vita, Bjoern Peters, Shane Crotty, Daniela Weiskopf, Alessandro Sette,

Immunotherapy and Immune Responses

Over the past year, numerous studies in the peer reviewed and preprint literature have reported on the virological, epidemiological and clinical characteristics of the coronavirus, SARS-CoV-2. To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings. We review how epitopes identified throughout the SARS-CoV2 proteome reveal significant correlation between number of epitopes defined and size of the antigen provenance. We also report additional analysis of SARS-CoV-2 human CD4 and CD8 T cell epitope data compiled from these studies, identifying 1,400 different reported SARS-CoV-2 epitopes and revealing discrete immunodominant regions of the virus and epitopes that are more prevalently recognized. This remarkable breadth of epitope repertoire has implications for vaccine design, cross-reactivity, and immune escape by SARS-CoV-2 variants.