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Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

2021; American Society for Clinical Investigation; Volume: 131; Issue: 14 Linguagem: Inglês

10.1172/jci149633

1558-8238

Lael M. Yonker, Tal Gilboa, Alana F. Ogata, Yasmeen Senussi, Roey Lazarovits, Brittany P. Boribong, Yannic C. Bartsch, Maggie Loiselle, Magali Noval Rivas, Rebecca A. Porritt, Rosiane Lima, Jameson P. Davis, E Farkas, Madeleine D. Burns, Nicola Young, Vinay S. Mahajan, Soroush Hajizadeh, Xcanda Ixchel Herrera Lopez, Johannes Kreuzer, Robert T. Morris, Enid E. Martinez, Isaac Han, Kettner Griswold, Nicholas C. Barry, David B. Thompson, George M. Church, Andrea G. Edlow, Wilhelm Haas, Shiv Pillai, Moshe Arditi, Galit Alter, David R. Walt, Alessio Fasano,

Systemic Lupus Erythematosus Research

BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in children (MIS-C). Gastrointestinal (GI) symptoms are common in patients with MIS-C, and a severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not been identified to date.