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Effectiveness of COVID-19 vaccines in preventing SARS-CoV-2 infection and hospitalisation, Navarre, Spain, January to April 2021

2021; European Centre for Disease Prevention and Control; Volume: 26; Issue: 21 Linguagem: Inglês

10.2807/1560-7917.es.2021.26.21.2100438

1560-7917

Iván Martínez‐Baz, Ana Miqueleiz, Itziar Casado, Ana Navascués, Camino Trobajo‐Sanmartín, Cristina Burgui, Marcela Guevara, Carmen Ezpeleta, Jesús Castilla,

COVID-19 epidemiological studies

COVID-19 vaccine effectiveness was evaluated in close contacts of cases diagnosed during January–April 2021. Among 20,961 contacts, 7,240 SARS-CoV-2 infections were confirmed, with 5,467 being symptomatic and 559 leading to hospitalisations. Non-brand-specific one and two dose vaccine effectiveness were respectively, 35% (95% confidence interval (CI): 25 to 44) and 66% (95% CI: 57 to 74) against infections, 42% (95% CI: 31 to 52) and 82% (95% CI: 74 to 88) against symptomatic infection, and 72% (95% CI: 47 to 85) and 95% (95% CI: 62 to 99) against COVID-19 hospitalisation. The second dose significantly increased effectiveness. Findings support continuing complete vaccination.