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Challenges in exploring and manipulating the human skin microbiome

2021; BioMed Central; Volume: 9; Issue: 1 Linguagem: Inglês

10.1186/s40168-021-01062-5

2049-2618

Manon Boxberger, Valérie Cenizo, Nadim Cassir, Bernard La Scola,

Nail Diseases and Treatments

Abstract The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation.