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BIBTEX RIS

Propranolol stimulates angiogenesis during healing of ischemic wounds

2013; Wiley; Volume: 27; Issue: S1 Linguagem: Inglês

10.1096/fasebj.27.1_supplement.754.5

1530-6860

Andréa Monte‐Alto‐Costa, Ana Carla Balthar Bandeira,

Diabetic Foot Ulcer Assessment and Management

The aim of this study was to evaluate the response to different doses of propranolol during cutaneous ischemic wound in rodents. Wistar rats were treated with propranolol at concentrations of 3 and 6 mg/kg/day, control group received only vehicle. Propranolol administration began on the day of injury, and was administered daily until euthanasia. Bilateral incisions were performed the dorsum of each animal. The flap was sutured and a full‐thickness wound was made between incisional lesions Propranolol treated with 3 mg group showed a reduction in total wound area when compared to control group. Also, propranolol treated with 3 mg group showed an increased of density of blood vessels, highest PECAM‐1 expression and highest blood perfusion in ischemic skin and in the wound bed when compared to control group. In summary, we suggest that propranolol administered at 3 mg/day was able to modulate angiogenesis and improved healing in this rodent model.