Artigo Acesso aberto Produção Nacional Revisado por pares

Involvement of GABAA Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal

2021; Hindawi Publishing Corporation; Volume: 2021; Linguagem: Inglês

10.1155/2021/9929805

ISSN

2314-6141

Autores

Jéssica Andrade, Álefe Brito Monteiro, Humberto Hugo Nunes de Andrade, Thallita Karla Silva do Nascimento Gonzaga, Pablo Rayff da Silva, Danielle da Nóbrega Alves, Ricardo Dias de Castro, Mayara dos Santos Maia, Marcus Tullius Scotti, Damião Pergentino de Sousa, Reinaldo Nóbrega de Almeida,

Tópico(s)

Essential Oils and Antimicrobial Activity

Resumo

Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evaluate the possible anxiolytic-like activity of HC and its possible mechanism of action using in vivo and in silico methodologies. Swiss male mice (Mus musculus) were treated with HC (12.5, 25, and 50 mg/kg, i.p.) and subjected to the rota rod, elevated plus maze, and open field tests. No significant impairments were observed in the rota rod tests for the motor activity of the animals treated with HC at 12.5, 25, and 50 mg/kg, i.p., indicating no myo-relaxing or sedative effects. In the elevated plus maze, HC (in the three doses) induced significant increases in the percentage of entries (respectively, 34.8%, 33.8%, and 38.6%) and in the length of stay (respectively, 49.9%, 56.1%, and 57.0%) in the open arms of the EPM, as well as the number of crossings in the open field tests. The mechanism of action of the compound's anxiolytic-like activity can be attributed to the involvement of GABAA receptors, and this interaction was observed in in vivo and in silico studies. For HC, the results suggest anxiolytic-like effects, possibly via modulation of the GABAergic system. The use of natural products to treat anxiety can become an alternative to existing synthetic products.

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