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An emerging role for BAG3 in gynaecological malignancies

2021; Springer Nature; Volume: 125; Issue: 6 Linguagem: Inglês

10.1038/s41416-021-01446-2

1532-1827

Margot De Marco, Antonia Falco, Roberta Iaccarino, Antonio Raffone, Antonio Mollo, Maurizio Guida, Alessandra Rosati, Massimiliano Chetta, Giovanni Genovese, Francesco De, Mario Capunzo, Maria Caterina Turco, Vladimir N. Uversky, Liberato Marzullo,

Enzyme Structure and Function

BAG3, a member of the BAG family of co-chaperones, is a multidomain protein with a role in several cellular processes, including the control of apoptosis, autophagy and cytoskeletal dynamics. The expression of bag3 is negligible in most cells but can be induced by stress stimuli or malignant transformation. In some tumours, BAG3 has been reported to promote cell survival and resistance to therapy. The expression of BAG3 has been documented in ovarian, endometrial and cervical cancers, and studies have revealed biochemical and functional connections of BAG3 with proteins involved in the survival, invasion and resistance to therapy of these malignancies. BAG3 expression has also been shown to correlate with the grade of dysplasia in squamous intraepithelial lesions of the uterine cervix. Some aspects of BAG3 activity, such as its biochemical and functional interaction with the human papillomavirus proteins, could help in our understanding of the mechanisms of oncogenesis induced by the virus. This review aims to highlight the potential value of BAG3 studies in the field of gynaecological tumours.