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Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

2019; Cell Press; Volume: 28; Issue: 12 Linguagem: Inglês

10.1016/j.celrep.2019.08.080

2639-1856

Smitha Krishnan, Yufang Ding, Nima Saeidi, Maria Choi, Gautham Sridharan, David H. Sherr, Martin L. Yarmush, Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee,

Diet and metabolism studies

(Cell Reports 23, 1099–1111; April 24, 2018) In the originally published version of this article, Dr. Nima Saeidi’s last name was misspelled. The correct spelling is Nima Saeidi. The authors regret this error. Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and MacrophagesKrishnan et al.Cell ReportsApril 24, 2018In BriefDysbiosis of the intestinal microbiota is an emerging factor contributing to the progression of fatty liver disease. Krishnan et al. utilize metabolomics and biochemical assays in conjunction with animal and cell culture models to identify microbiota-dependent metabolites that engage a host receptor to affect liver inflammatory responses under lipid loading. Full-Text PDF Open Access