Portal de Periódicos da CAPES

Acute regulation of insulin-like growth factor-I gene expression by growth hormone during adipose cell differentiation.

1987; Springer Nature; Volume: 6; Issue: 13 Linguagem: Inglês

10.1002/j.1460-2075.1987.tb02744.x

1460-2075

Alain Doglio, Christian Dani, Gudrun Fredrikson, P Grimaldi, Gérard Ailhaud,

Lipid metabolism and disorders

Research Article20 December 1987free access Acute regulation of insulin-like growth factor-I gene expression by growth hormone during adipose cell differentiation. A. Doglio A. Doglio Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author C. Dani C. Dani Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author G. Fredrikson G. Fredrikson Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author P. Grimaldi P. Grimaldi Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author G. Ailhaud G. Ailhaud Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author A. Doglio A. Doglio Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author C. Dani C. Dani Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author G. Fredrikson G. Fredrikson Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author P. Grimaldi P. Grimaldi Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author G. Ailhaud G. Ailhaud Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. Search for more papers by this author Author Information A. Doglio1, C. Dani1, G. Fredrikson1, P. Grimaldi1 and G. Ailhaud1 1Centre de Biochimie du CNRS, Faculté des Sciences, Nice, France. The EMBO Journal (1987)6:4011-4016https://doi.org/10.1002/j.1460-2075.1987.tb02744.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Insulin-like growth factor I (IGF-I) is a mitogenic polypeptide that is thought to play, under the control of growth hormone, a role in fetal development as well as post-natally. The direct effect of growth hormone on the regulation of the expression of IGF-I gene was examined in adipose Ob1771 cells. Growth hormone regulates the abundance of multiple species of IGF-I mRNAs of 15, 7.5, 1.5 and 0.8 kb in a differentiation-dependent manner. The regulation of IGF-I gene expression is strikingly rapid (less than 2 h), reversible and takes place primarily at transcriptional level. Thus growth hormone can increase the cellular content of IGF-I mRNA encoding for a protein which could be involved in a paracrine/autocrine action during adipose tissue development. Previous ArticleNext Article Volume 6Issue 131 December 1987In this issue RelatedDetailsLoading ...