Expression of Exogenous Epithelial Sodium Channel Beta Subunit in the Mouse Middle Cerebral Artery Increases Pressure-Induced Constriction
2021; Oxford University Press; Volume: 34; Issue: 11 Linguagem: Inglês
10.1093/ajh/hpab098
ISSN1941-7225
AutoresZoltán Németh, Michael J. Ryan, Joey P. Granger, Heather A. Drummond,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoPressure-induced constriction (PIC) is inherent to small arteries and arterioles, in which intraluminal pressure-induced vascular smooth muscle cell stretch elicits vasoconstriction. Degenerin (Deg) proteins, such as beta-epithelial Na+ channel (βENaC), have been studied in the PIC response because they are evolutionarily linked to known mechanosensors. While loss of Deg function phenotypes are plentiful, a gain-of-function phenotype has not been studied. The aim of this study was to determine if expression of exogenous βENaC in the isolated middle cerebral artery (MCA) enhances the PIC response.
Referência(s)