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Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology

2021; Multidisciplinary Digital Publishing Institute; Volume: 26; Issue: 13 Linguagem: Inglês

10.3390/molecules26133795

1433-1373

James N. Tsoporis, Ioannis-Alexandros Drosatos, Sahil Gupta, Hajera Amatullah, Shehla Izhar, Claúdia C. dos Santos, Vasileos Salpeas, Angelos G. Rigopoulos, Ioannis K. Toumpoulis, Andreas S. Triantafyllis, Eleftharios Sakadakis, Nikolaos Kavantzas, John C. Marshall, Ioannis Rizos, Thomas G. Parker,

Cardiovascular, Neuropeptides, and Oxidative Stress Research

DJ-1 was originally identified as an oncogene product while mutations of the gene encoding DJ-1/PARK7 were later associated with a recessive form of Parkinson’s disease. Its ubiquitous expression and diversity of function suggest that DJ-1 is also involved in mechanisms outside the central nervous system. In the last decade, the contribution of DJ-1 to the protection from ischemia-reperfusion injury has been recognized and its involvement in the pathophysiology of cardiovascular disease is attracting increasing attention. This review describes the current and gaps in our knowledge of DJ-1, focusing on its role in regulating cardiovascular function. In parallel, we present original data showing an association between increased DJ-1 expression and antiapoptotic and anti-inflammatory markers following cardiac and vascular surgical procedures. Future studies should address DJ-1’s role as a plausible novel therapeutic target for cardiovascular disease.